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What is SLOP-1®?

SLOP-1 exerts its therapeutic effect through selective modulation of synaptic vesicle fusion machinery via SNARE complex conformational “splice gating.” By transiently favoring an alternative synaptobrevin–syntaxin interface configuration, it reprograms neurotransmitter release probability in excitatory neurons without altering basal firing rates. This mechanism recalibrates synaptic output with exquisite spatial precision, resulting in stabilized excitatory/inhibitory balance across neural circuits implicated in cognitive and mood regulation. Downstream, this “splice gating” facilitates synaptic homeostasis by preventing pathological vesicle depletion and aberrant potentiation while preserving physiological plasticity. The controlled reconfiguration of vesicle priming harmonizes neurotransmission dynamics, ensuring predictable network responsiveness and durable functional improvement without receptor desensitization or maladaptive remodeling.

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